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upliFT-D trial key

  • Name: upliFT-D
  • Treatment: PBFT02
  • Goal: Study the effectiveness and safety of a new gene therapy, PBFT02, in people with FTD caused by a GRN or C9orf72 mutation
  • Ages eligible: 35 to 75 years old

Frontotemporal Dementia (FTD) upliFT-D Clinical Trial

Information for people with FTD and their caregivers

studying a potential new therapy

Passage Bio is studying a potential new therapy called PBFT02 for the treatment of frontotemporal dementia caused by a GRN mutation (FTD-GRN) or a C9orf72 mutation (FTD-C9orf72).

gene therapy

PBFT02 is a novel investigational therapy intended to increase progranulin (PGRN) levels in people with FTD-GRN or FTD-C9orf72. Preliminary evidence has shown that increasing these levels may slow the effects of FTD in animals.*

PBFT02 has not been approved in any market.

help people

This clinical trial, called upliFT-D, is studying if PBFT02 can help people with FTD-GRN or FTD-C9orf72.

people between the ages of 35 and 75

People between the ages of 35 and 75 who are diagnosed with FTD and a confirmed GRN or C9orf72 mutation will be included in this study. There are other criteria that determine eligibility, which may be discussed with a healthcare provider.

If you don't know if you have a GRN or C9orf72 genetic mutation, click here for more information.

Contact Passage Bio to learn more:

We are here to help and we're happy to answer any questions you may have about FTD, the treatment we are studying, and the clinical trial.

Please fill out the form to the right below to contact Passage Bio. If you or your loved one is interested in participating in the study, please include the information listed below:

  • Age
  • Diagnosis
  • Language preference

*Required

 
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Learn about the upliFT-D trial

This video shares important information about the upliFT-D clinical trial, which is studying a possible new treatment for people living with FTD. It covers what you and your care partner can expect if you decide to take part—details about the therapy being studied, and how Passage Bio will be there to support you every step of the way.